By ALEX VEIGA AP Business Writer

Stocks are down sharply on Wall Street as data showing new coronavirus cases in the U.S. have climbed to the highest level in two months rattles investors' optimism for a relatively quick economic turnaround. 

The S&P 500 was down 2.2% in afternoon trading Wednesday, giving back all of its gains for the week. The selling, which followed a skid in European stock indexes, accelerated around mid-morning on news that New York, New Jersey and Connecticut will require visitors from states with high infection rates to quarantine for 14 days. 

While economic data is pointing to a recovery from the spring lockdowns that are being eased in the U.S. and other countries, the rise in new infections is stoking worries that the reopening of businesses may have to be curtailed again. 

"We've created this optimistic trade over the last few weeks," said J.J. Kinahan, chief strategist with TD Ameritrade. "Are we going to be able to get back to business as fast as it has been priced into equities?"

Technology companies, which have been leading the market higher as it bounced back from a plunge in March, accounted for the biggest slice of the market's pullback. Financial, health care, communication services and industrial sector stocks also took heavy losses. Energy stocks were down the most as the price of oil dropped sharply.

Cruise lines, which would stand to suffer greatly if travel restrictions are extended, were among the biggest losers in the S&P 500. Norwegian Cruise Line, Carnival and Royal Caribbean Cruises were each down more than 10%. Hotel operators also were down sharply. Wynn Resorts and MGM Resorts International were each down more than 7%.

The Dow Jones Industrial Average was down 652 points, or 2.5%, to 25,504. The Nasdaq, which was coming off its second all-time high this week, was down 2%. The Russell 2000 index of small company stocks gave up 3.8%. 

The market has been mostly in rally mode since April as investors focused on the prospects for an economic turnaround as broad areas of the economy reopened. Recently, some encouraging economic reports have fueled optimism that the reopening of businesses in the U.S. and elsewhere could pull the economy out of a deep recession sooner rather than later. 

But the recent surge in new infections is undercutting some of that optimism. Coronavirus hospitalizations and caseloads have hit new highs in over a half-dozen U.S. states. New cases nationwide are back near their peak level of two months ago. 

While early hot spots like New York and New Jersey have seen cases steadily decrease, the virus has been hitting the south and west. Several states on Tuesday set single-day records, including Arizona, California, Mississippi, Nevada and Texas. 

On Tuesday, Federal health officials told Congress to brace for a second wave of coronavirus infections in the fall and winter of this year.

"There's the possibility of shutdowns, but probably more realistically delays in reopening," Kinahan said. "This puts doubt on how comfortable people will be getting on a plane or staying in hotels."

Analysts are warning that, despite recent market rallies, there is little reassurance infections won't keep spreading, given the growing numbers in some parts of the U.S., Brazil and Asia. 

Prakash Sapal, senior economist for ING, said the focus is slowly shifting back to the COVID-19 pandemic from optimism about a rebound from loosening lockdown restrictions.

"The recent acceleration in infections has rekindled concern that governments will be forced to shut down their economies once again, squandering the chance for the much-hoped-for economic bounce back," he said in a report.

Major stock indexes in Europe also fell broadly. Germany's DAX dropped 2.8%, while France's CAC 40 slid 2.3%. Britain's FTSE 100 was down 2.5%. Markets in Asia closed mostly higher. 

The yield on the 10-year Treasury note held steady at 0.70%. It tends to move with investors' expectations for the economy and inflation.

In energy trading, benchmark U.S. crude oil slid 5.5% to $38.14 a barrel. Brent crude, the international standard, was down 5.4% to $40.43.